MOLECULAR GENETICS LABORATORY 

​2025

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• Sharma S, Basak SK, Das S, Alone DP. Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population. FEBS Open Bio. 2025 Feb 19. doi: 10.1002/2211-5463.70006.

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• Hayat B, Panigrahi S, Behera SR, Mohanty PP, Alone DP. Susceptibility to pseudoexfoliation linked to intronic variant rs4926246 in CACNA1A: Evidence from an Indian population study. Biochim Biophys Acta Gene Regul Mech. 2025 Mar;1868(1):195076. doi: 10.1016/j.bbagrm.2025.195076.

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• Karmakar S, Mallik M, Sulava S, Modi U, Allu S, Sangwan S, Tothadi S, Prakasha Reddy J, Vasita R, Nangia AK, Alone DP, Prabhakaran P. Fluorescent p53 helix mimetics pairing anticancer and bioimaging properties. Biomater Sci. 2025 Feb 26. doi: 10.1039/d4bm01681e.

 

2023

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• Kapuganti RS, Alone DP. Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma. Mol Aspects Med. 2023 Sep 18;94:101214.

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• Kapuganti RS, Sahoo L, Mohanty PP, Hayat B, Parija S, Alone DP. Role of clusterin gene 3'-UTR polymorphisms and promoter hypomethylation in the pathogenesis of pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Biochim Biophys Acta Gene Regul Mech. 2023 Aug 29;1866(4):194980.

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• Kapuganti RS, Hayat B, Padhy B, Mohanty PP, Alone DP. Dickkopf-1 and ROCK2 upregulation and associated protein aggregation in pseudoexfoliation syndrome and glaucoma. Life Sci. 2023 May 20:121797.

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• Padhy B, Kapuganti RS, Hayat B, Mohanty PP, Alone DP. Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression. Gene. 2023 Feb 20; 854:147096.

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• Chakraborty M, Jandhyam H, Basak SK, Das S, Alone DP. Intergenic variants, rs1200114 and rs1200108 are genetically associated along with a decreased ATP1B1 expression in Fuchs Endothelial Corneal Dystrophy. Experimental Eye Research. 2023 Mar; 228:109403.

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• Kapuganti RS, Bharati B, Mohanty PP, Alone DP. Genetic variants and haplotypes in fibulin-5 (FBLN5) are associated with pseudoexfoliation glaucoma but not with pseudoexfoliation syndrome. Bioscience Reports. 2023 Mar 31; 43(3): BSR20221622.

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2022​

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• Ramani Shyam Kapuganti, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Quantitative analysis of circulating levels of vimentin, clusterin and fibulin-5 in patients with pseudoexfoliation syndrome and glaucoma. Experimental Eye Research. 2022 Nov; 224:109236.

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• Maynak Chakraborty, Rajesh Kumar Das, Sujata Samal, Sujata Das, Debasmita Pankaj Alone. Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B. Gene. 2022 Apr 5; 817:146179.

 

2021​

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• Biswajit Padhy and Debasmita Pankaj Alone. Is pseudoexfoliation glaucoma a neurodegenerative disorder? J Biosciences, 2021, 46:97

 

​2020

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• Rakesh Mishra, Rohit Kunar, Lolitika Mandal, Debasmita Pankaj Alone, Shanti Chandrasekharan, Anand Kumar Tiwari, Madhu Gwaldas Tapadia, Asim Mukherjee, Jagat Kumar Roy. A forward genetic approach to mapping a P-Element second site mutation identifies DCP2 as a novel tumor suppressor in Drosophila melanogaster.G3: Genes, Genomes, Genetics, 2020, 10 (8): 2601-2618.

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• Bushra Hayat, Ramani Shyam Kapuganti, Biswajit Padhy, Pranjya Paramita Mohanty & Debasmita Pankaj Alone. Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma. Journal of Human Genetics, 2020, doi: 10.1038/s10038-020-0736-8.

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2019

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• Padhy B, Kapuganti RS, Hayat B, Mohanty PP, Alone DP. De novo variants in an extracellular matrix protein coding gene, fibulin-5 (FBLN5) are associated with pseudoexfoliation. European Journal of Human Genetics, 2019, doi: 10.1038/s41431-019-0482-6.

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• Gargi Gouranga Nanda and Debasmita Pankaj Alone. REVIEW: Current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy.  Molecular Vision, 2019, 25: 295-310.

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• Bushra Hayat, Biswajit Padhy, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis. Experimental Eye Research, 2019, 181: 197-207.

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2018

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• Gargi Gouranga Nanda, Malloji Vinay Kumar, Laxmipriya Pradhan, Biswajit Padhy, Satabdi Sundaray, Sujata Das, Debasmita Pankaj Alone. rs4246215 is targeted by hsa-miR1236 to regulate FEN1 expression but is not associated with Fuchs' endothelial corneal dystrophy. PLOS ONE, 2018, 13 (9): e0204278. 

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2017

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• Biswajit Padhy, Bushra Hayat, Gargi Gouranga Nanda, Pranjya Paramita Mohanty, Debasmita Pankaj Alone. Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590 lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression. Human Molecular Genetics, 2017, 26 (22): 4519–4529.

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2014

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• Phom Limamanen, Achumi Bovita, Alone Debasmita P, Muralidhara M, Yenisetti S C. Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease is Phase Specific: Implication of its Therapeutic Effectiveness. Rejuvenation Res., 2014, 17 (6): 481-9.

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• Nanda Gargi G, Padhy Biswajit, Samal Sujata, Das Sujata, Alone Debasmita P. Genetic association of TCF4 intronic polymorphisms, CTG18.1 and rs17089887, with Fuchs' endothelial corneal dystrophy in an Indian population. Investigative Ophthalmology & Visual Science, 2014, 55 (11):7674-80.

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• Padhy Biswajit, Nanda Gargi G, Chowdhury Mahesweta, Padhi Debanand, Rao Aparna, Alone Debasmita P. Role of an extracellular chaperone, clusterin in the pathogenesis of pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Experimental Eye Research, 2014, 127: 69-76.

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• Das Sourajit S, Nanda Gargi G, Alone Debasmita P. Artemisinin and Curcumin inhibit Drosophila brain tumor, prolong life span, and restore locomotor activity. IUBMB Life, 2014 66: 496-506.

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2009

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• Alone Debasmita P, Rodriguez Jason C, Noland Cameron L and Nash Howard A. Impact of copy number variation on Anesthesia in Drosophila melanogaster. Anesthesiology, 2009, 111, 15-24

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2008

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• Tiwari Anand K, Alone Debasmita P and Roy Jagat K. Rab11 is essential for fertility in Drosophila. Cell Biology International, 2008, 32, 1158-1168.

 

2005

 

• Alone Debasmita P, Scott Robert L and Nash Howard A. An Ion Channel that Influences Anesthesia Sensitivity: Designing a Genetic Test for Assessing a Candidate Anesthetic Target. Int. Congress Series, 2005, 1283, 119-125.

 

• Alone Debasmita P, Tiwari Anand K, Mandal Lolitika, Li Mingfa, Mechler Bernard M and Roy Jagat K. Rab11 is required during Drosophila eye development. Int. J Dev Biol. 2005, 49, 873-879.

 

 

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